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KMID : 1134819980270030537
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Journal of the Korean Society of Food Science and Nutrition
1998 Volume.27 No. 3 p.537 ~ p.542
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Elucidation of Anti - Tumor Initiator and Promoter Derived from Seaweed - 4 : Desmutagenic Principles of Ecklonia stolonifera Extracts against Carcinogenic Heterocyclic Amines
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Park Yeung-Beom
Ahn Jong-Khan
Yoo Sung-Jae
Park Douck-Choun
Kim In-Soo
Park Yeung-Ho
Kim Seon-Bong
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Abstract
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The present study was performed to elucidate desmutagenic principles from Ecklonia stolonifera extracts against 2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine(PhIP) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline{MeIQx) with Salmonella/mammalian-microsome mutagenicity test. Alginate, phenols, chlorophyll and carotenoids from Ecklonia stolonifera were extracted and their desmutagenicities were assayed. Alginate hydrolysates showed desmutagenic activities against PhIP and MeIQx at high level dose. Phenol fractions and bromophenol showed desmutagenic activity of about 90% per 0.5㎎ against PhIP and MeIQx. Chlorophyllin among chlorophyll derivatives exhibited remarkable desmutagenic activities of 92.9% and 82.7% at 20μM against PhIP and MeIQx, respectively. Carotenoids, such as lutein and α-cryptoxanthin isolated from Ecklonia stolonifera exerted also high desmutagenic activity. Major desmutagenic substances from Ecklonia stolonifera are considered to be chlorophyllin, phenols, lutein, α-cryptoxanthin and low molecular alginates.
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KEYWORD
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PhIP, MeIQx, Ecklonia stolonifera, chlorophyllin, lutein, ${\alpha}$-cryptoxanthin
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